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"Blood stem cell transfusions recover faster and
have fewer complications," Keuroghelian said. "Survival
outcomes have improved. Patients used to die during
transplants due to complications, but we have really
reduced that. I've seen their quality of life improve."
These improvements also are allowing doctors and nurses
to treat older patients than in the past. Sharon Steingass,
MSN, RN, a clinical nurse specialist at City of Hope,
recently treated a man in his 70s who had lymphoma.
"Several years ago, we would have never considered
transplanting because of his age," she said. "The
chemotherapy and radiation would have been too hard
on him, and then there is still the recovery period.
Now, we could give him less chemo and radiation, and
use blood for stem cells instead of marrow. Now, this
man is doing well."
The next jump came in the late 1990s, when researchers
began probing the potential uses of embryonic stem cells.
They discovered that cells from an early fertilized
egg had the capacity to develop into other tissues of
the body.
"The dream was that under the right conditions,
we could coax these cells to develop into liver cells,
heart cells, brain cells," Forman said. "So
work is being done to see if these stem cells can be
used to repair brain injury from a stroke or Parkinson's
disease, or even might be able to make insulin for diabetics."
Most of the time, these stem cells were from unused
fertilized eggs from couples who had pursued fertility
treatment, and this ushered in a moral dilemma because
the eggs could represent human beings, Forman said.
"Nurses have to be very aware of the ethical aspects,"
Middleton said. "Patients who may need stem cell
therapy may face people who are critical of the use
of stem cells. Some patients themselves may be in conflict,
and nurses can help them in the decision process."
Steingass believes that many people have moral objections
because embryonic stem cell research has the potential
to advance human cloning technology. "A lot of
people have difficulty with the cloning aspect, but
not the embryonic component," she said.
Both technologies take an egg, remove the nucleus and
replace it with a different nucleus, Forman explained.
For a diabetic, this new egg could be used to develop
new pancreatic cells to reverse the effects of diabetes.
But critics argue that this technology also could be
used to clone human beings.
But Forman said researchers are working on techniques
that could bypass the moral issues and still take advantage
of stem cell treatments. Evidence shows that cells in
the brain can produce blood, and this reveals the potential
that a cell in one tissue can develop into the cell
of another tissue, he said.
"I'm very optimistic," Steingass said. "I
know it's not going to be overnight, but I don't think
you can stop science. It continues to move ahead."
Like Middleton, Steingass encourages nurses to gear
up to use these treatments of the future by returning
to the molecular basics they learned in nursing school.
This kind of knowledge will be more important than ever
as the technology moves out of the lab and into the
hospital.
"In order for us to truly take care of patients,
we will have to be comfortable with the molecular and
genetic aspects of these treatments," she said.
"We as nurses are going to have to go back to the
anatomy textbooks and familiarize ourselves with what
happens at the cellular levels. So many of the new treatments
will require that we understand molecular things at
the cellular level."
Contact Heather Stringer at heathers@nurseweek.com
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