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All Things Considered
As the safety of hormone drug Prempro sits in question, women re-evaluate homone replacement therapy choices

 
 

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The National Institutes of Health halted the use of Prempro in the Women's Health Initiative, a study that set out to determine whether the combination of estrogen plus progestin did prevent heart disease and fractures. When the WHI data and safety monitoring board discovered that women using Prempro in the study had a higher risk of heart attack, stroke, blood clots and breast cancer, the board recommended stopping the trial.

Mary Koithan never expected her trek through the maze of midlife hormones to be humiliating, or for that matter, public.

The assistant professor of nursing at the University of Arizona found herself standing in front of dozens of students when she started to forget the names of authors she was quoting. As if her brain had mysteriously shorted out, she struggled for minutes on end to grasp questions the students asked in class.

The symptoms also plagued the professor outside of work. The grocery store was like a foreign country filled with foods she couldn't identify. There were severe panic attacks, then hot flashes. Koithan, Ph.D., RN, felt as though she was on the edge of Alzheimer's disease at age 45.

"I felt like I would have to retire because I couldn't think, couldn't make words come out of my mouth," she said. "My job depends on my ability to think and speak clearly. It was horrible."

Koithan soon discovered that her crippling mental and emotional crises were linked to two simple-yet amazingly complex-hormones: estrogen and progesterone. It wasn't until she started hormone replacement therapy that she began to recover her sanity.

Like many middle-aged women, Koithan relies on HRT to pump her body with hormones that stave off everything from hot flashes to poor concentration to panic attacks. But this summer, the safety of these hormone drugs was called into question when the National Institutes of Health abruptly halted the use of Prempro in the Women's Health Initiative (WHI), a study that set out to determine whether the combination of estrogen plus progestin-a synthetic form of progesterone-did prevent heart disease and hip fractures.

When the WHI data and safety monitoring board discovered that women using Prempro in the study had a higher risk of heart attack, stroke, blood clots and breast cancer, the board recommended stopping the trial.

The news left as many as 6 million American women in a wake of fear and confusion as they were compelled to re-evaluate their decisions about using HRT. Although the study's results give menopausal women ammunition to make more informed decisions, nurse practitioners and doctors interviewed by NURSEWEEK agreed that women should avoid the temptation to overlook the advantages of taking hormones. These health professionals are adamant that each woman needs to consider both quality-of-life benefits from HRT and the potential risks-and her personal values will greatly influence that final decision.

Informed decisions

Before people can make these choices, though, nurses such as Martha Drohobyczer, MSN, RN, believe that women need to take the time to understand the study's results.

"The statistics were not that alarming, but there's enough that we need to do further research," said Drohobyczer, a certified nurse-midwife at Alternatives for Women in Las Vegas.

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