Silent Weapons
Growing fear of bioterrorism prompts action

The worldwide eradication of smallpox was seen as a great public health victory. But in June, U.S. intellegence officials discovered that some countries may have stores of the virus (shown above) intended for military use.
 
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Why Worry Now?

Biological weapons aren’t new. But it’s only in the last few years that several events knocked the public health community out of its complacency.

The defection of Russian bioweapons experts during this decade raised concerns that more countries would have access to potentially dangerous biological expertise, said Raouf Arafat, MD, MPH, chief of epidemiology for the City Health Department in Houston. The discovery in June that Iraq, Russia, and North Korea likely have concealed stashes of the smallpox virus also sent shivers through the public health community. Because the disease has been eradicated, no one has been immunized against it since the 1980s.

In 1998, California, Indiana, Kentucky, and Tennessee were the sites of bioterrorist threats of anthrax exposure, according to the CDC. Though no contamination was found, the allegations set the disaster response network into action and convinced officials that they needed to improve the public health infrastructure in case of a real biological assault.

The 1995 release of sarin gas into a Tokyo subway by the Japanese cult Aum Shinrikyo convinced many that chemical and biological agents were no longer just weapons of war. In 1998, it was learned that Aum Shinrikyo “actually tried to aerosolize anthrax on a number of occasions in downtown Tokyo. They failed, primarily because they had the wrong organism,” said D.A. Henderson, MD, MPH, director of the Johns Hopkins University Center for Civilian Biodefense Studies in Baltimore.

~ Anne Federwisch, OTR

 

   
     
     

Have a Plan

Being aware and prepared is crucial to combatting bioterrorism, experts say. One of the easiest ways to gather information is to go online.

Bioterrorism Preparedness and Response
A great place to start. The national Centers for Disease Control and Prevention presents a wealth of details at this site. Link to several in-depth articles, including the Bioterrorism Readiness Plan: A Template for Healthcare Facilities, and fact sheets on anthrax, botulism, plague, and viral hemorrhagic fevers. You can also access the Feb. 5, 1999, Morbidity and Mortality Weekly Report, which details the 1998 anthrax hoaxes and treatment for anthrax exposure.

Association for Professionals in Infection Control and Epidemiology Inc.
Another terrific site. Includes an excellent compilation of bioterrorism resources. The Bioterrorism Readiness Plan: A Template for Healthcare Facilities (a joint project with the CDC) can be downloaded in Word format, so you can easily revise it to meet your facility’s needs.

Public Health Grand Rounds
Good information at this site. Presented by the University of North Carolina at Chapel Hill School of Public Health and the CDC. Allows you to view the June 11, 1999, bioterrorism grand rounds, as well as the handouts. Includes links to resources elsewhere on the Web for dealing with bioterrorism.

Johns Hopkins University Center for Civilian Biodefense Studies
Lots to look at here. Includes highlights from the February 1999 national symposium on bioterrorism. View the talks or read summaries. Topics include vaccines, smallpox, anthrax, concerns about Russia and Iraq, and the epidemiology of bioterrorism.

American Public Health Association
A more general site, but a few bioterrorism-related tidbits. Order a copy of Control of Communicable Disease Manual, or link to the continuing education page for descriptions and registration for courses on bioterrorism.

~ Anne Federwisch, OTR

   

By Anne Federwisch, OTR
Photo: Custom Medical Stock Photo
July 26, 1999

Civilian nurses could well be the first responders to a bioterrorist attack—but they might not realize it initially. Victims could look as if they had the flu or a cold. But if the weapon were aerosolized anthrax, those seemingly commonplace symptoms might escalate to respiratory distress and death in only a couple of days for thousands of victims, experts warn.

What was once the exclusive realm of the military has become a leading public health concern. Although the armed forces have long been interested in biological weapons, nonmilitary organizations such as the national Centers for Disease Control and Prevention (CDC), the Association for Professionals in Infection Control and Epidemiology Inc. (APIC), the American Public Health Association (APHA), and disaster planners nationwide are beginning to focus on bioterrorism.

“It wouldn’t be the military who are responding to the patients,” explained Donna E. Davis, MPH, project director for Public Health Grand Rounds for the University of North Carolina at Chapel Hill. In June, the school in conjunction with the CDC presented a program on bioterrorism.

What’s the difference?

Previously, civilian training for responding to bioterrorism went to traditional first responders to a tragedy, such as police, firefighters, and rescue workers, said D. A. Henderson, MD, MPH, director of the Johns Hopkins University Center for Civilian Biodefense Studies in Baltimore. The organization was established in September 1998 to spearhead efforts to respond effectively to bioterrorist threats.

“When it comes to a biological event, that’s an epidemic,” Henderson said. “The whole first responder group is different than for chemical or explosive events.” Victims will likely initially trickle into emergency rooms and healthcare facilities looking for relief of symptoms such as nausea, respiratory problems, fever, or myalgia. Health professionals need a good understanding of potential biologic agents and of the appropriate response to the resulting disease to minimize its effect and spread.

Detecting bioweapons is difficult. They leave no visible fingerprint until their toxins steadily decimate a population. Unlike nuclear weaponry, biologic agents require no telltale equipment to produce. “Purely from a public health standpoint,” said Mohammad Akhter, MD, MPH, executive director of APHA, “the threat is real because these are concealed substances that can’t be detected by any means that we know.”

Silent assault

This insidious nature is one of the foremost challenges of reacting to bioterrorism. Attacks will likely transpire without fanfare, such as the silent release of an agent like anthrax or smallpox, experts predict.

“We’re not likely to know that it occurred until the first case is diagnosed,” said certified infection control nurse Judith English, MSN, RN, chair of the bioterrorism task force for APIC and head of the infection control branch of the infectious diseases division at the National Naval Medical Center in Bethesda, Md. “It doesn’t smell; it’s invisible. It would just be by syndromes— which healthcare providers need to be aware of— that an attack could be identified,” she said.

Timely response requires recognizing an assault’s aftermath quickly. Bioterrorism needs to be in the back of all health professionals’ minds whenever they begin to see large numbers of patients with similar symptoms, said Rachel Stevens, EdD, RN, director of the public health nursing program at the University of North Carolina at Chapel Hill. “A cluster of similar symptoms should make any nurse suspicious,” Stevens said. A close look at the epidemiology of the outbreak could then confirm or refute bioterrorism as the source and set in motion effective response measures.

Healthcare response

Key to an efficient response, English said, is having policies and procedures in place that can be accessed readily. She is co-author of Bioterrorism Readiness Plan: A Template for Healthcare Facilities, a joint project of APIC and the CDC. The plan can be downloaded from either agencies’ Web sites free of charge (www.apic.org/html/educ/readinow.html and www.cdc.gov/NCIDOD/HIP/Bio/bio.htm) and can be easily modified to meet a facility’s needs. The guide divulges agent-specific recommendations for anthrax, botulism, plague, and smallpox. It also describes infection control practices, postexposure management, patient information, and reporting requirements.

Even if terrorism hasn’t been determined as a cause, suspicious symptoms need to be reported immediately to local infection control personnel, hospital administration, and local and state health departments, English said. She recommends notifying the FBI field office, local police, the CDC, and medical emergency services. The readiness plan includes phone numbers for many of these agencies and leaves room to write in local numbers.

Communication between agencies is critical to a coordinated effort, said Raouf Arafat, MD, MPH, chief of epidemiology for the City Health Department in Houston. Too often, health professionals delay contacting the health department to report suspicious signs and symptoms, no matter what the origin. Hesitancy in reporting can obscure the big picture and hamper spotting an outbreak in the early stages, he said.

Nurses’ roles after a bioterrorist incident would be similar to their usual jobs. “Infection control professionals would do the gumshoe investigation: Where was this person that could have been exposed to this organism that has been diagnosed?” English said. “We have this experience in our daily work life.”

But the scope would probably be on a much larger scale in the event of bioterrorism, Henderson said. “A lot of disease goes around, whether at a church picnic or whatever, but it doesn’t bring a city to its knees,” he said. Anthrax, smallpox, plague, botulism, hemorraghic fevers, and other biologic agents could cripple a city’s population and its economy.

Preparation as deterrence

“The better prepared we are, the less likely we are to have such an event,” Henderson said. “If it’s recognized that we’re prepared to respond quickly and effectively, then a biological weapon is less likely to be selected for use.”

By being prepared for a possible bioterrorist attack, healthcare systems are also ready to combat naturally occurring infections, he said. “What we need to do is come out of the complacency we’ve had about infectious disease,” Henderson said. Many people feel that infectious disease is confined to our past, he said, yet new virulent diseases are developing all the time. Henderson cautioned, “We’ve got to be alert and ready to deal with new and emerging infections, whether natural or man-made.”